Haley E. Titus, PhD

At the Miami University Leadershape Retreat in the summer of 2005 I defined my vision; to find a cure for Multiple Sclerosis (MS) as my mother has secondary progressive MS. The steps I have taken so far include graduating from Miami University with a minor in neuroscience and graduating from Wright State University with a Master’s in Science after performing research as part of Dr. Alvarez’s Lab with a project on the extent of reformation of inhibitory synapses on injured/regenerating neurons and alteration of their properties. I performed my dissertation research at the University of Cincinnati College of Medicine, Cincinnati Children’s Hospital Medical Center as part of Dr. Nancy Ratner’s Lab with a project on disruption of white matter tracts in the central nervous system in gain of function Rasopathies.  Additionally, I have had the pleasure of serving on the National Multiple Sclerosis Society, Ohio Valley Chapter board and currently serve the National Multiple Sclerosis Society, Greater Illinois Chapter as a member of the associate board as Advocacy Chair. I am elated to work in the lab of Dr. Stephen D. Miller at Northwestern School of Medicine, in the department of Microbiology and Immunology as a post-doctoral fellow generously supported by the National Multiple Sclerosis Society (2015-2018).  My project on immunoregulatory and myelin repair therapeutics in T-Cell mediated mouse models of Multiple Sclerosis tests that combination therapy of immune regulation (i.e. only turning off the part of the immune system that is disrupted in MS) with myelin repair therapy could slow/ prevent further relapses and promote repair of damage. These pre-clinical trials may provide a novel and safe targeted approach that can be translated into effective disease-modifying therapies for MS patients. I intend to continue to work in translational medicine with a focus on remyelination and neuroimmunology.

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